Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth

Oncogenic RAS mutant (RAS(MUT)) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS–targeting IgG antibody, inRas37, which directly targets the intracellularly acti...

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Vydáno v:Sci Adv
Hlavní autoři: Shin, Seung-Min, Kim, Ji-Sun, Park, Seong-Wook, Jun, Sei-Yong, Kweon, Hye-Jin, Choi, Dong-Ki, Lee, Dakeun, Cho, Yong Beom, Kim, Yong-Sung
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962039/
https://ncbi.nlm.nih.gov/pubmed/31998840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay2174
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