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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration

Oncogenic Ras mutants, frequently detected in human cancers, are high-priority anticancer drug targets. However, direct inhibition of oncogenic Ras mutants with small molecules has been extremely challenging. Here we report the development of a human IgG1 format antibody, RT11, which internalizes in...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Shin, Seung-Min, Choi, Dong-Ki, Jung, Keunok, Bae, Jeomil, Kim, Ji-sun, Park, Seong-wook, Song, Ki-Hoon, Kim, Yong-Sung
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436137/
https://ncbi.nlm.nih.gov/pubmed/28489072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15090
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