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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
Oncogenic Ras mutants, frequently detected in human cancers, are high-priority anticancer drug targets. However, direct inhibition of oncogenic Ras mutants with small molecules has been extremely challenging. Here we report the development of a human IgG1 format antibody, RT11, which internalizes in...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5436137/ https://ncbi.nlm.nih.gov/pubmed/28489072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15090 |
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