Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.
Two dominant inhibitory Ras mutant proteins were analyzed by microinjection. One, [Asn-17]Ras, had a substitution in the putative Mg(2+)-binding site of Ha-Ras. The other, RAST, had a mutation in a yeast RAS protein that impaired its GTPase activity and increased its affinity for GAP. RAST also had...
Guardat en:
| Publicat a: | Mol Cell Biol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1991
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2072908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.8.4053-4064.1991 |
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