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Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

Two dominant inhibitory Ras mutant proteins were analyzed by microinjection. One, [Asn-17]Ras, had a substitution in the putative Mg(2+)-binding site of Ha-Ras. The other, RAST, had a mutation in a yeast RAS protein that impaired its GTPase activity and increased its affinity for GAP. RAST also had...

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Udgivet i:Mol Cell Biol
Principais autores: Stacey, D W, Feig, L A, Gibbs, J B
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361212/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2072908/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.8.4053-4064.1991
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