Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

Two dominant inhibitory Ras mutant proteins were analyzed by microinjection. One, [Asn-17]Ras, had a substitution in the putative Mg(2+)-binding site of Ha-Ras. The other, RAST, had a mutation in a yeast RAS protein that impaired its GTPase activity and increased its affinity for GAP. RAST also had...

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Publicado en:	Mol Cell Biol
Principais autores:	Stacey, D W, Feig, L A, Gibbs, J B
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis 1991
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361212/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2072908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.8.4053-4064.1991
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