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Towards a mechanistic understanding of DNA methylation readout by transcription factors

Epigenetic DNA modification impacts gene expression, but the underlying molecular mechanisms are only partly understood. Adding a methyl group to a cytosine base locally modifies the structural features of DNA in multiple ways, which may change the interaction with DNA-binding transcription factors...

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Detalles Bibliográficos
Publicado en:J Mol Biol
Main Authors: Kribelbauer, Judith F., Lu, Xiang-Jun, Rohs, Remo, Mann, Richard S., Bussemaker, Harmen J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961349/
https://ncbi.nlm.nih.gov/pubmed/31689433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.10.021
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