Systematic prediction of DNA shape changes due to CpG methylation explains epigenetic effects on protein–DNA binding

BACKGROUND: DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited. Cytosine methylation, the most frequent modification, represents the addition of a methyl gr...

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Vydáno v:Epigenetics Chromatin
Hlavní autoři: Rao, Satyanarayan, Chiu, Tsu-Pei, Kribelbauer, Judith F., Mann, Richard S., Bussemaker, Harmen J., Rohs, Remo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800008/
https://ncbi.nlm.nih.gov/pubmed/29409522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0174-4
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