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Low-Affinity Binding Sites and the Transcription Factor Specificity Paradox in Eukaryotes
Eukaryotic transcription factors (TFs) from the same structural family tend to bind similar DNA sequences, despite the ability of these TFs to execute distinct functions in vivo. The cell partly resolves this specificity paradox through combinatorial strategies and the use of low-affinity binding si...
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| Publicado no: | Annu Rev Cell Dev Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6787930/ https://ncbi.nlm.nih.gov/pubmed/31283382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-cellbio-100617-062719 |
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