Accurate and sensitive quantification of protein-DNA binding affinity

Transcription factors (TFs) control gene expression by binding to genomic DNA in a sequence-specific manner. Mutations in TF binding sites are increasingly found to be associated with human disease, yet we currently lack robust methods to predict these sites. Here, we developed a versatile maximum l...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Rastogi, Chaitanya, Rube, H. Tomas, Kribelbauer, Judith F., Crocker, Justin, Loker, Ryan E., Martini, Gabriella D., Laptenko, Oleg, Freed-Pastor, William A., Prives, Carol, Stern, David L., Mann, Richard S., Bussemaker, Harmen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
Schlagworte:
PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910815/
https://ncbi.nlm.nih.gov/pubmed/29610332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714376115
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