Structural determinants of phorbol ester binding activity of the C1a and C1b domains of protein kinase C theta

The PKC isozymes represent the most prominent family of signaling proteins mediating response to the ubiquitous second messenger diacylglycerol. Among them, PKCθ is critically involved in T-cell activation. Whereas all the other conventional and novel PKC isoforms have twin C1 domains with potent bi...

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Gepubliceerd in:Biochim Biophys Acta Biomembr
Hoofdauteurs: Czikora, Agnes, Pany, Satyabrata, You, Youngki, Saini, Amandeep S., Lewin, Nancy E., Mitchell, Gary A., Abramovitz, Adelle, Kedei, Noemi, Blumberg, Peter M., Das, Joydip
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957261/
https://ncbi.nlm.nih.gov/pubmed/29317197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.01.007
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