Munc13 Is a Molecular Target of Bryostatin 1

[Image: see text] Bryostatin 1 is a natural macrolide shown to improve neuronal connections and enhance memory in mice. Its mechanism of action is largely attributed to the modulation of novel and conventional protein kinase Cs (PKCs) by binding to their regulatory C1 domains. Munc13-1 is a C1 domai...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Blanco, Francisco A., Czikora, Agnes, Kedei, Noemi, You, Youngki, Mitchell, Gary A., Pany, Satyabrata, Ghosh, Anamitra, Blumberg, Peter M., Das, Joydip
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620733/
https://ncbi.nlm.nih.gov/pubmed/31243993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00427
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