Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibro...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Maity, Sangeeta, Muhamed, Jaseer, Sarikhani, Mohsen, Kumar, Shweta, Ahamed, Faiz, Spurthi, Kondapalli Mrudula, Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Arathi, Bangalore Prabhashankar, Desingu, Perumal Arumugam, Sundaresan, Nagalingam R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956532/
https://ncbi.nlm.nih.gov/pubmed/31744885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007212
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