Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibro...

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Опубликовано в: :J Biol Chem
Главные авторы: Maity, Sangeeta, Muhamed, Jaseer, Sarikhani, Mohsen, Kumar, Shweta, Ahamed, Faiz, Spurthi, Kondapalli Mrudula, Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Arathi, Bangalore Prabhashankar, Desingu, Perumal Arumugam, Sundaresan, Nagalingam R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956532/
https://ncbi.nlm.nih.gov/pubmed/31744885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007212
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