Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice

Toll-like receptors (TLRs) are a family of pattern-recognition receptors involved in innate immunity. Previous studies have shown that TLR2 inhibition protects the heart from acute stress, including myocardial infarction and doxorubicin-induced cardiotoxicity in animal models. However, the role of T...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Spurthi, Kondapalli Mrudula, Sarikhani, Mohsen, Mishra, Sneha, Desingu, Perumal Arumugam, Yadav, Shikha, Rao, Swathi, Maity, Sangeeta, Tamta, Ankit Kumar, Kumar, Shweta, Majumdar, Shamik, Jain, Aditi, Raghuraman, Aishwarya, Khan, Danish, Singh, Ishwar, Samuel, Rosa J., Ramachandra, Subbaraya G., Nandi, Dipankar, Sundaresan, Nagalingam R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109936/
https://ncbi.nlm.nih.gov/pubmed/29929978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001880
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