Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice

Toll-like receptors (TLRs) are a family of pattern-recognition receptors involved in innate immunity. Previous studies have shown that TLR2 inhibition protects the heart from acute stress, including myocardial infarction and doxorubicin-induced cardiotoxicity in animal models. However, the role of T...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Spurthi, Kondapalli Mrudula, Sarikhani, Mohsen, Mishra, Sneha, Desingu, Perumal Arumugam, Yadav, Shikha, Rao, Swathi, Maity, Sangeeta, Tamta, Ankit Kumar, Kumar, Shweta, Majumdar, Shamik, Jain, Aditi, Raghuraman, Aishwarya, Khan, Danish, Singh, Ishwar, Samuel, Rosa J., Ramachandra, Subbaraya G., Nandi, Dipankar, Sundaresan, Nagalingam R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109936/
https://ncbi.nlm.nih.gov/pubmed/29929978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001880
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