Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibro...

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Publicado en:J Biol Chem
Autores principales: Maity, Sangeeta, Muhamed, Jaseer, Sarikhani, Mohsen, Kumar, Shweta, Ahamed, Faiz, Spurthi, Kondapalli Mrudula, Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Arathi, Bangalore Prabhashankar, Desingu, Perumal Arumugam, Sundaresan, Nagalingam R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956532/
https://ncbi.nlm.nih.gov/pubmed/31744885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007212
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