Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibro...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Maity, Sangeeta, Muhamed, Jaseer, Sarikhani, Mohsen, Kumar, Shweta, Ahamed, Faiz, Spurthi, Kondapalli Mrudula, Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Arathi, Bangalore Prabhashankar, Desingu, Perumal Arumugam, Sundaresan, Nagalingam R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956532/
https://ncbi.nlm.nih.gov/pubmed/31744885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007212
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