Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibro...

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Pubblicato in:J Biol Chem
Autori principali: Maity, Sangeeta, Muhamed, Jaseer, Sarikhani, Mohsen, Kumar, Shweta, Ahamed, Faiz, Spurthi, Kondapalli Mrudula, Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Arathi, Bangalore Prabhashankar, Desingu, Perumal Arumugam, Sundaresan, Nagalingam R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956532/
https://ncbi.nlm.nih.gov/pubmed/31744885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007212
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