SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

Global protein synthesis is emerging as an important player in the context of aging and age-related diseases. However, the intricate molecular networks that regulate protein synthesis are poorly understood. Here, we report that SIRT6, a nuclear-localized histone deacetylase represses global protein...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Ahamed, Faiz, Mishra, Sneha, Giri, Malyasree, Inbaraj, Meena, Krishna, Swati, Sarikhani, Mohsen, Maity, Sangeeta, Kumar, Shweta, Shah, Riyaz Ahmad, Dave, Pratik, Pandit, Anwit S, Rajendran, Rajprabu, Desingu, Perumal A, Varshney, Umesh, Das, Saumitra, Kolthur-Seetharam, Ullas, Rajakumari, Sona, Singh, Mahavir, Sundaresan, Nagalingam R
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755095/
https://ncbi.nlm.nih.gov/pubmed/31372634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz648
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