SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

Global protein synthesis is emerging as an important player in the context of aging and age-related diseases. However, the intricate molecular networks that regulate protein synthesis are poorly understood. Here, we report that SIRT6, a nuclear-localized histone deacetylase represses global protein...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ravi, Venkatraman, Jain, Aditi, Khan, Danish, Ahamed, Faiz, Mishra, Sneha, Giri, Malyasree, Inbaraj, Meena, Krishna, Swati, Sarikhani, Mohsen, Maity, Sangeeta, Kumar, Shweta, Shah, Riyaz Ahmad, Dave, Pratik, Pandit, Anwit S, Rajendran, Rajprabu, Desingu, Perumal A, Varshney, Umesh, Das, Saumitra, Kolthur-Seetharam, Ullas, Rajakumari, Sona, Singh, Mahavir, Sundaresan, Nagalingam R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755095/
https://ncbi.nlm.nih.gov/pubmed/31372634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz648
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