Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved when diplotype assignments incorporate structural var...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Clin Transl Sci
मुख्य लेखकों: Dalton, Rachel, Lee, Seung‐been, Claw, Katrina G., Prasad, Bhagwat, Phillips, Brian R., Shen, Danny D., Wong, Lai Hong, Fade, Mitch, McDonald, Matthew G., Dunham, Maitreya J., Fowler, Douglas M., Rettie, Allan E., Schuetz, Erin, Thornton, Timothy A., Nickerson, Deborah A., Gaedigk, Andrea, Thummel, Kenneth E., Woodahl, Erica L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2019
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951848/
https://ncbi.nlm.nih.gov/pubmed/31536170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12695
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