Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved when diplotype assignments incorporate structural var...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Dalton, Rachel, Lee, Seung‐been, Claw, Katrina G., Prasad, Bhagwat, Phillips, Brian R., Shen, Danny D., Wong, Lai Hong, Fade, Mitch, McDonald, Matthew G., Dunham, Maitreya J., Fowler, Douglas M., Rettie, Allan E., Schuetz, Erin, Thornton, Timothy A., Nickerson, Deborah A., Gaedigk, Andrea, Thummel, Kenneth E., Woodahl, Erica L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951848/
https://ncbi.nlm.nih.gov/pubmed/31536170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12695
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