Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved when diplotype assignments incorporate structural var...

詳細記述

保存先:
書誌詳細
出版年:Clin Transl Sci
主要な著者: Dalton, Rachel, Lee, Seung‐been, Claw, Katrina G., Prasad, Bhagwat, Phillips, Brian R., Shen, Danny D., Wong, Lai Hong, Fade, Mitch, McDonald, Matthew G., Dunham, Maitreya J., Fowler, Douglas M., Rettie, Allan E., Schuetz, Erin, Thornton, Timothy A., Nickerson, Deborah A., Gaedigk, Andrea, Thummel, Kenneth E., Woodahl, Erica L.
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951848/
https://ncbi.nlm.nih.gov/pubmed/31536170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12695
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