Transfer learning enables prediction of CYP2D6 haplotype function

Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in CYP2D6 are responsible for interindividual heterogeneity in drug response that can lead to drug toxicity and ineffective treatment, making CYP2D6...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: McInnes, Gregory, Dalton, Rachel, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Lee, Seung-been, Tsao, Philip S., Gaedigk, Andrea, Altman, Russ B., Woodahl, Erica L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660895/
https://ncbi.nlm.nih.gov/pubmed/33137098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008399
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