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Prediction of CYP2D6 phenotype from genotype across world populations

PURPOSE: Owing to its highly polymorphic nature and major contribution to the metabolism and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively studied drug-metabolizing enzymes and pharmacogenes. CYP2D6 alleles confer no, decreased, normal, or increased activity...

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Detalhes bibliográficos
Publicado no:Genet Med
Main Authors: Gaedigk, Andrea, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Klein, Teri, Leeder, J. Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292679/
https://ncbi.nlm.nih.gov/pubmed/27388693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2016.80
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