CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele

Cytochrome P450 (CYP) 2D6, a major contributor to the metabolism and bioactivation of many clinically used drugs, is encoded by a complex, highly polymorphic gene locus. To aid in the characterization of CYP2D6 allelic variation, we developed allele-specific long-range PCR (ASXL-PCR) to amplify only...

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Udgivet i:J Mol Diagn
Main Authors: Gaedigk, Andrea, Riffel, Amanda K., Leeder, J. Steven
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2015
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630174/
https://ncbi.nlm.nih.gov/pubmed/26335396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2015.06.007
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