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Structural Mechanism of a Rag GTPase Activation Checkpoint by the Lysosomal Folliculin Complex

The tumor suppressor Folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) Activating Protein (GAP) activity toward the GTPase RagC. Concomitant with mTORC1 inactivation by starvation...

詳細記述

保存先:
書誌詳細
出版年:Science
主要な著者: Lawrence, Rosalie E., Fromm, Simon A., Fu, Yangxue, Yokom, Adam L., Kim, Do Jin, Thelen, Ashley M., Young, Lindsey N., Lim, Chun-Yan, Samelson, Avi J., Hurley, James H., Zoncu, Roberto
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6945816/
https://ncbi.nlm.nih.gov/pubmed/31672913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax0364
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