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Structural Mechanism of a Rag GTPase Activation Checkpoint by the Lysosomal Folliculin Complex
The tumor suppressor Folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) Activating Protein (GAP) activity toward the GTPase RagC. Concomitant with mTORC1 inactivation by starvation...
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| Izdano u: | Science |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6945816/ https://ncbi.nlm.nih.gov/pubmed/31672913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax0364 |
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