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Rag GTPases are cardioprotective by regulating lysosomal function

The Rag family proteins are Ras-like small GTPases that play a critical role in amino acid-stimulated mTORC1 activation by recruiting mTORC1 to lysosome. Despite progress in the mechanistic understanding of Rag GTPases in mTORC1 activation, little is known about the physiological function of Rag GTP...

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Detalhes bibliográficos
Main Authors: Kim, Young Chul, Park, Hyun Woo, Sciarretta, Sebastiano, Mo, Jung-Soon, Jewell, Jenna L., Russell, Ryan C., Wu, Xiaohui, Sadoshima, Junichi, Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100214/
https://ncbi.nlm.nih.gov/pubmed/24980141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5241
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