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Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

The mTORC1 complex supports cell growth and proliferation in response to energy levels, growth factors, and nutrients. The Rag guanosine triphosphatases (GTPases) activate mTORC1 in response to amino acids by promoting its redistribution to lysosomes. In this paper, we identify a novel role for Rags...

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Autors principals: Martina, Jose A., Puertollano, Rosa
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575543/
https://ncbi.nlm.nih.gov/pubmed/23401004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201209135
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