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RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis

When the levels of intracellular amino acids are high, RRAG GTPases recruit MTORC1 to lysosomes and promote its activation. We found that RRAGs also recruit specific MTORC1 substrates to the lysosomal surface, thus facilitating MTORC1-mediated phosphorylation and regulation. In particular, active RR...

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Détails bibliographiques
Auteurs principaux: Martina, Jose A., Puertollano, Rosa
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672304/
https://ncbi.nlm.nih.gov/pubmed/23524842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24371
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