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Regulation of autophagy by lysosomal positioning
The mammalian target of rapamycin (mTOR) is a well-conserved negative regulator of autophagy. Here we review our recent data describing how lysosomal positioning influences and coordinates mTOR activity, autophagosome biogenesis and autophagosome-lysosome fusion. In this way, lysosomal positioning r...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149695/ https://ncbi.nlm.nih.gov/pubmed/21521941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.8.15862 |
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