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RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis
When the levels of intracellular amino acids are high, RRAG GTPases recruit MTORC1 to lysosomes and promote its activation. We found that RRAGs also recruit specific MTORC1 substrates to the lysosomal surface, thus facilitating MTORC1-mediated phosphorylation and regulation. In particular, active RR...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Landes Bioscience
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672304/ https://ncbi.nlm.nih.gov/pubmed/23524842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.24371 |
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