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TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

Lysosomal distribution is linked to the role of lysosomes in many cellular functions, including autophagosome degradation, cholesterol homeostasis, antigen presentation, and cell invasion. Alterations in lysosomal positioning contribute to different human pathologies, such as cancer, neurodegenerati...

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Foilsithe in:Nat Commun
Main Authors: Willett, Rose, Martina, José A., Zewe, James P., Wills, Rachel, Hammond, Gerald R. V., Puertollano, Rosa
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691037/
https://ncbi.nlm.nih.gov/pubmed/29146937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01871-z
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