YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases

Lysosomal dysfunction caused by mutations in lysosomal genes results in lysosomal storage disorder (LSD), characterized by accumulation of damaged proteins and organelles in cells and functional abnormalities in major organs, including the heart, skeletal muscle, and liver. In LSD, autophagy is inhi...

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Опубликовано в: :J Clin Invest
Главные авторы: Ikeda, Shohei, Nah, Jihoon, Shirakabe, Akihiro, Zhai, Peiyong, Oka, Shin-ichi, Sciarretta, Sebastiano, Guan, Kun-Liang, Shimokawa, Hiroaki, Sadoshima, Junichi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919732/
https://ncbi.nlm.nih.gov/pubmed/33373332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143173
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