In vivo elongation of thin filaments results in heart failure

A novel cardiac-specific transgenic mouse model was generated to identify the physiological consequences of elongated thin filaments during post-natal development in the heart. Remarkably, increasing the expression levels in vivo of just one sarcomeric protein, Lmod2, results in ~10% longer thin fil...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mi-Mi, Lei, Farman, Gerrie P., Mayfield, Rachel M., Strom, Joshua, Chu, Miensheng, Pappas, Christopher T., Gregorio, Carol C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941805/
https://ncbi.nlm.nih.gov/pubmed/31899774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226138
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