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Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins
The Frank–Starling mechanism of the heart is due, in part, to modulation of myofilament Ca(2+) sensitivity by sarcomere length (SL) [length-dependent activation (LDA)]. The molecular mechanism(s) that underlie LDA are unknown. Recent evidence has implicated the giant protein titin in this cellular p...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776536/ https://ncbi.nlm.nih.gov/pubmed/26858417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516732113 |
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