Energy landscapes reveal the myopathic effects of tropomyosin mutations

Por Orzechowski, Marek, Fischer, Stefan, Moore, Jeffrey R., Lehman, William, Farman, Gerrie P.
Publicado no Arch Biochem Biophys (2014)

Thick-Filament Strain and Interfilament Spacing in Passive Muscle: Effect of Titin-Based Passive Tension

Por Irving, Thomas, Wu, Yiming, Bekyarova, Tanya, Farman, Gerrie P., Fukuda, Norio, Granzier, Henk
Publicado em 2011

Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH(2) terminus of the RLC on β-myosin cross-bridge mechanics

Por Farman, Gerrie P., Muthu, Priya, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
Publicado no J Appl Physiol (1985) (2014)

Interfilament Spacing Is Preserved during Sarcomere Length Isometric Contractions in Rat Cardiac Trabeculae

Por Farman, Gerrie P., Allen, Edward J., Gore, David, Irving, Thomas C., de Tombe, Pieter P.
Publicado em 2007

The Role of Thin Filament Cooperativity in Cardiac Length-Dependent Calcium Activation

Por Farman, Gerrie P., Allen, Edward J., Schoenfelt, Kelly Q., Backx, Peter H., de Tombe, Pieter P.
Publicado em 2010

Myosin head orientation: a structural determinant for the Frank-Starling relationship

Por Farman, Gerrie P., Gore, David, Allen, Edward, Schoenfelt, Kelly, Irving, Thomas C., de Tombe, Pieter P.
Publicado em 2011

Myofilament Length Dependent Activation

Por de Tombe, Pieter P., Mateja, Ryan D., Kittipong-Tachampa, Mou, Younss Ait, Farman, Gerrie P., Irving, Thomas C.
Publicado em 2010

Thick-to-Thin Filament Surface Distance Modulates Cross-Bridge Kinetics in Drosophila Flight Muscle

Por Tanner, Bertrand C.W., Farman, Gerrie P., Irving, Thomas C., Maughan, David W., Palmer, Bradley M., Miller, Mark S.
Publicado em 2012

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

Por Ait-Mou, Younss, Hsu, Karen, Farman, Gerrie P., Kumar, Mohit, Greaser, Marion L., Irving, Thomas C., de Tombe, Pieter P.
Publicado no Proc Natl Acad Sci U S A (2016)

Phosphorylation and the N-terminal Extension of the Regulatory Light Chain Help Orient and Align the Myosin Heads in Drosophila Flight Muscle

Por Farman, Gerrie P., Miller, Mark S., Reedy, Mary C., Soto-Adames, Felipe N., Vigoreaux, Jim O., Maughan, David W., Irving, Thomas C.
Publicado em 2009

Regulatory Light Chain Phosphorylation and N-Terminal Extension Increase Cross-Bridge Binding and Power Output in Drosophila at In Vivo Myofilament Lattice Spacing

Por Miller, Mark S., Farman, Gerrie P., Braddock, Joan M., Soto-Adames, Felipe N., Irving, Thomas C., Vigoreaux, Jim O., Maughan, David W.
Publicado em 2011

Aging Enhances Indirect Flight Muscle Fiber Performance yet Decreases Flight Ability in Drosophila

Por Miller, Mark S., Lekkas, Panagiotis, Braddock, Joan M., Farman, Gerrie P., Ballif, Bryan A., Irving, Thomas C., Maughan, David W., Vigoreaux, Jim O.
Publicado em 2008

Alternative S2 Hinge Regions of the Myosin Rod Affect Myofibrillar Structure and Myosin Kinetics

Por Miller, Mark S., Dambacher, Corey M., Knowles, Aileen F., Braddock, Joan M., Farman, Gerrie P., Irving, Thomas C., Swank, Douglas M., Bernstein, Sanford I., Maughan, David W.
Publicado em 2009

Hypertrophic Cardiomyopathy Associated Lys104Glu Mutation in the Myosin Regulatory Light Chain Causes Diastolic Disturbance in Mice

Por Huang, Wenrui, Liang, Jingsheng, Kazmierczak, Katarzyna, Muthu, Priya, Duggal, Divya, Farman, Gerrie P., Sorensen, Lars, Pozios, Iraklis, Abraham, Theodore P., Moore, Jeffrey R., Borejdo, Julian, Szczesna-Cordary, Danuta
Publicado em 2014

Phosphodiesterase 4D (PDE4D) regulates baseline sarcoplasmic reticulum Ca(2+) release and cardiac contractility, independently of L-type Ca(2+)current

Por Beca, Sanja, Helli, Peter B., Simpson, Jeremy A., Zhao, Dongling, Farman, Gerrie P., Jones, Peter, Tian, Xixi, Wilson, Lindsay S., Ahmad, Faiyaz, Chen, S.R. Wayne, Movsesian, Matthew A., Manganiello, Vincent, Maurice, Donald H., Conti, Marco, Backx, Peter H.
Publicado em 2011

Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα

Por Aschar-Sobbi, Roozbeh, Izaddoustdar, Farzad, Korogyi, Adam S., Wang, Qiongling, Farman, Gerrie P., Yang, FengHua, Yang, Wallace, Dorian, David, Simpson, Jeremy A., Tuomi, Jari M., Jones, Douglas L., Nanthakumar, Kumaraswamy, Cox, Brian, Wehrens, Xander H.T., Dorian, Paul, Backx, Peter H.
Publicado no Nat Commun (2015)

A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila

Por Achal, Madhulika, Trujillo, Adriana S., Melkani, Girish C., Farman, Gerrie P., Ocorr, Karen, Viswanathan, Meera C., Kaushik, Gaurav, Newhard, Christopher S., Glasheen, Bernadette M., Melkani, Anju, Suggs, Jennifer A., Moore, Jeffrey R., Swank, Douglas M., Bodmer, Rolf, Cammarato, Anthony, Bernstein, Sanford I.
Publicado no J Mol Biol (2016)

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His–Purkinje network

Por Zhang, Shan-Shan, Kim, Kyoung-Han, Rosen, Anna, Smyth, James W., Sakuma, Rui, Delgado-Olguín, Paul, Davis, Mark, Chi, Neil C., Puviindran, Vijitha, Gaborit, Nathalie, Sukonnik, Tatyana, Wylie, John N., Brand-Arzamendi, Koroboshka, Farman, Gerrie P., Kim, Jieun, Rose, Robert A., Marsden, Phillip A., Zhu, Yonghong, Zhou, Yu-Qing, Miquerol, Lucile, Henkelman, R. Mark, Stainier, Didier Y. R., Shaw, Robin M., Hui, Chi-chung, Bruneau, Benoit G., Backx, Peter H.
Publicado em 2011