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Energy landscapes reveal the myopathic effects of tropomyosin mutations

Striated muscle contraction is regulated by an interaction network connecting the effects of troponin, Ca(2+), and myosin-heads to the azimuthal positioning of tropomyosin along thin filaments. Many missense mutations, located at the actin-tropomyosin interface, however, reset the regulatory switchi...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Orzechowski, Marek, Fischer, Stefan, Moore, Jeffrey R., Lehman, William, Farman, Gerrie P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258436/
https://ncbi.nlm.nih.gov/pubmed/25241052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.09.007
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