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Energy landscapes reveal the myopathic effects of tropomyosin mutations
Striated muscle contraction is regulated by an interaction network connecting the effects of troponin, Ca(2+), and myosin-heads to the azimuthal positioning of tropomyosin along thin filaments. Many missense mutations, located at the actin-tropomyosin interface, however, reset the regulatory switchi...
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| Опубликовано в: : | Arch Biochem Biophys |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258436/ https://ncbi.nlm.nih.gov/pubmed/25241052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.09.007 |
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