Hypertrophic Cardiomyopathy Associated Lys104Glu Mutation in the Myosin Regulatory Light Chain Causes Diastolic Disturbance in Mice

We have examined, for the first time, the effects of the familial hypertrophic cardiomyopathy (HCM)- associated Lys104Glu mutation in the myosin regulatory light chain (RLC). Transgenic mice expressing the Lys104Glu substitution (Tg-MUT) were generated and the results compared to Tg-WT (wild-type hu...

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Detalhes bibliográficos
Main Authors: Huang, Wenrui, Liang, Jingsheng, Kazmierczak, Katarzyna, Muthu, Priya, Duggal, Divya, Farman, Gerrie P., Sorensen, Lars, Pozios, Iraklis, Abraham, Theodore P., Moore, Jeffrey R., Borejdo, Julian, Szczesna-Cordary, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115013/
https://ncbi.nlm.nih.gov/pubmed/24992035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.06.011
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