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Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain

Myosin regulatory light chain (RLC) phosphorylation is important for cardiac muscle mechanics/function as well as for the Ca(2+)-troponin/tropomyosin regulation of muscle contraction. This study focuses on the arginine to glutamine (R58Q) substitution in the human ventricular RLC (MYL2 gene), linked...

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Bibliografische gegevens
Gepubliceerd in:FEBS J
Hoofdauteurs: Yadav, Sunil, Kazmierczak, Katarzyna, Liang, Jingsheng, Sitbon, Yoel H., Szczesna-Cordary, Danuta
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326841/
https://ncbi.nlm.nih.gov/pubmed/30430732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14702
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