Ablation of the N terminus of cardiac essential light chain promotes the super-relaxed state of myosin and counteracts hypercontractility in hypertrophic cardiomyopathy mutant mice

In this study, we focus on the molecular mechanisms associated with the A57G (Ala57-to-Gly57) mutation in myosin essential light chains (ELCs), found to cause hypertrophic cardiomyopathy (HCM) in humans and in mice. Specifically, we studied the effects of A57G on the super-relaxed (SRX) state of myo...

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Publicado en:FEBS J
Autores principales: Sitbon, Yoel H., Kazmierczak, Katarzyna, Liang, Jingsheng, Yadav, Sunil, Veerasammy, Melanie, Kanashiro-Takeuchi, Rosemeire M., Szczesna-Cordary, Danuta
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888128/
https://ncbi.nlm.nih.gov/pubmed/32034976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15243
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