Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

AIMS: The E143K (Glu → Lys) mutation in the myosin essential light chain has been associated with restrictive cardiomyopathy (RCM) in humans, but the mechanisms that underlie the development of defective cardiac function are unknown. Using transgenic E143K-RCM mice, we sought to determine the molecu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cardiovasc Res
Prif Awduron: Yuan, Chen-Ching, Kazmierczak, Katarzyna, Liang, Jingsheng, Kanashiro-Takeuchi, Rosemeire, Irving, Thomas C., Gomes, Aldrin V., Wang, Yihua, Burghardt, Thomas P., Szczesna-Cordary, Danuta
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852631/
https://ncbi.nlm.nih.gov/pubmed/28371863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx060
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