Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice

AIMS: The E143K (Glu → Lys) mutation in the myosin essential light chain has been associated with restrictive cardiomyopathy (RCM) in humans, but the mechanisms that underlie the development of defective cardiac function are unknown. Using transgenic E143K-RCM mice, we sought to determine the molecu...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Yuan, Chen-Ching, Kazmierczak, Katarzyna, Liang, Jingsheng, Kanashiro-Takeuchi, Rosemeire, Irving, Thomas C., Gomes, Aldrin V., Wang, Yihua, Burghardt, Thomas P., Szczesna-Cordary, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852631/
https://ncbi.nlm.nih.gov/pubmed/28371863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvx060
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