Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice

Dilated cardiomyopathy (DCM) is a devastating heart disease that affects about 1 million people in the United States, but the underlying mechanisms remain poorly understood. In this study, we aimed to determine the biomechanical and structural causes of DCM in transgenic mice carrying a novel mutati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yuan, Chen-Ching, Kazmierczak, Katarzyna, Liang, Jingsheng, Zhou, Zhiqun, Yadav, Sunil, Gomes, Aldrin V., Irving, Thomas C., Szczesna-Cordary, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877945/
https://ncbi.nlm.nih.gov/pubmed/29463717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716925115
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