Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice

Myosin light chain kinase (MLCK)-dependent phosphorylation of the regulatory light chain (RLC) of cardiac myosin is known to play a beneficial role in heart disease, but the idea of a phosphorylation-mediated reversal of a hypertrophic cardiomyopathy (HCM) phenotype is novel. Our previous studies on...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yuan, Chen-Ching, Muthu, Priya, Kazmierczak, Katarzyna, Liang, Jingsheng, Huang, Wenrui, Irving, Thomas C., Kanashiro-Takeuchi, Rosemeire M., Hare, Joshua M., Szczesna-Cordary, Danuta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522794/
https://ncbi.nlm.nih.gov/pubmed/26124132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505819112
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