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Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH(2) terminus of the RLC on β-myosin cross-bridge mechanics

Familial hypertrophic cardiomyopathy (HCM) is associated with mutations in sarcomeric proteins, including the myosin regulatory light chain (RLC). Here we studied the impact of three HCM mutations located in the NH(2) terminus of the RLC on the molecular mechanism of β-myosin heavy chain (MHC) cross...

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Detalhes bibliográficos
Publicado no:J Appl Physiol (1985)
Main Authors: Farman, Gerrie P., Muthu, Priya, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269682/
https://ncbi.nlm.nih.gov/pubmed/25324513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00798.2014
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