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Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH(2) terminus of the RLC on β-myosin cross-bridge mechanics

Familial hypertrophic cardiomyopathy (HCM) is associated with mutations in sarcomeric proteins, including the myosin regulatory light chain (RLC). Here we studied the impact of three HCM mutations located in the NH(2) terminus of the RLC on the molecular mechanism of β-myosin heavy chain (MHC) cross...

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Dades bibliogràfiques
Publicat a:J Appl Physiol (1985)
Autors principals: Farman, Gerrie P., Muthu, Priya, Kazmierczak, Katarzyna, Szczesna-Cordary, Danuta, Moore, Jeffrey R.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269682/
https://ncbi.nlm.nih.gov/pubmed/25324513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00798.2014
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