Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

The Frank–Starling mechanism of the heart is due, in part, to modulation of myofilament Ca(2+) sensitivity by sarcomere length (SL) [length-dependent activation (LDA)]. The molecular mechanism(s) that underlie LDA are unknown. Recent evidence has implicated the giant protein titin in this cellular p...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ait-Mou, Younss, Hsu, Karen, Farman, Gerrie P., Kumar, Mohit, Greaser, Marion L., Irving, Thomas C., de Tombe, Pieter P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776536/
https://ncbi.nlm.nih.gov/pubmed/26858417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516732113
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