Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS...

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Publicat a:Transl Oncol
Autors principals: Kuo, Macus Tien, Long, Yan, Tsai, Wen-Bin, Li, Ying-Ying, Chen, Helen H.W., Feun, Lynn G., Savaraj, Niramol
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2019
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Original article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938815/
https://ncbi.nlm.nih.gov/pubmed/31887630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.12.003
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