Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Many human malignancies require extracellular arginine (Arg) for survival because the key enzyme for de novo Arg biosynthesis, argininosuccinate synthetase 1 (ASS1), is silenced. Recombinant arginine deiminase (ADI-PEG20), which digests extracellular Arg, has been in clinical trials for treating ASS...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Transl Oncol
Main Authors: Kuo, Macus Tien, Long, Yan, Tsai, Wen-Bin, Li, Ying-Ying, Chen, Helen H.W., Feun, Lynn G., Savaraj, Niramol
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press 2019
Teme:
Original article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938815/
https://ncbi.nlm.nih.gov/pubmed/31887630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2019.12.003
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