Gas6/Axl is the sensor of Arginine-Auxotrophic Response in Targeted Chemotherapy with Arginine-Depleting Agents

Many human malignancies lack de novo biosynthesis of arginine (Arg) because the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced. These tumors acquire ectopic Arg for survival, and depleting this source by Arg-depleting recombinant enzyme ADI-PEG20 results in cell death. Mechanisms under...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Tsai, Wen-Bin, Long, Yan, Park, Jeong-Ran, Chang, Jeffrey T., Liu, Hui, Rodriguez-Canales, Jaime, Savaraj, Niramol, Feun, Lynn G., Davies, Michael A., Wistuba, Ignacio I, Kuo, Macus Tien
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835044/
https://ncbi.nlm.nih.gov/pubmed/26096933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.237
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