Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts

Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...

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Publicat a:Bioorg Chem
Autors principals: Zheng, Maggie, Hwang, Seokjin, Snyder, Timothy, Aquilina, Jake, Proni, Gloria, Paz, Manuel M., Pradhan, Padmanava, Cheng, Shu-Yuan, Champeil, Elise
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/
https://ncbi.nlm.nih.gov/pubmed/31539740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280
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