Llwytho...

Isolation and Rationale for the Formation of Isomeric Decarbamoylmitomycin C-N(6)-deoxyadenosine Adducts in DNA

Mitomycin C (MC) is an anti-cancer agent which alkylates DNA to form monoadducts and interstrand crosslinks (ICLs). Decarbamoylmitomycin C (DMC) is an analog of MC lacking the carbamate on C10. The major DNA adducts isolated from treatment of culture cells with MC and DMC are N(2)-deoxyguanosine (dG...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Res Toxicol
Prif Awduron: Zacarias, Owen, Aguilar, William, Paz, Manuel M., Tsukanov, Sergey, Zheng, Maggie, Cheng, Shu-Yuan, Pradhan, Padmanava, Champeil, Elise
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061421/
https://ncbi.nlm.nih.gov/pubmed/30035537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00102
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