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Isolation and Rationale for the Formation of Isomeric Decarbamoylmitomycin C-N(6)-deoxyadenosine Adducts in DNA
Mitomycin C (MC) is an anti-cancer agent which alkylates DNA to form monoadducts and interstrand crosslinks (ICLs). Decarbamoylmitomycin C (DMC) is an analog of MC lacking the carbamate on C10. The major DNA adducts isolated from treatment of culture cells with MC and DMC are N(2)-deoxyguanosine (dG...
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| Publicat a: | Chem Res Toxicol |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7061421/ https://ncbi.nlm.nih.gov/pubmed/30035537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.8b00102 |
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