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Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts
Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...
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| 出版年: | Bioorg Chem |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/ https://ncbi.nlm.nih.gov/pubmed/31539740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280 |
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