Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts

Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Bioorg Chem
Huvudupphovsmän: Zheng, Maggie, Hwang, Seokjin, Snyder, Timothy, Aquilina, Jake, Proni, Gloria, Paz, Manuel M., Pradhan, Padmanava, Cheng, Shu-Yuan, Champeil, Elise
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/
https://ncbi.nlm.nih.gov/pubmed/31539740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk