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Synthesis of Mitomycin C and Decarbamoylmitomycin C N(6) deoxyadenosine-adducts
Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells pr...
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| Publicado no: | Bioorg Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936608/ https://ncbi.nlm.nih.gov/pubmed/31539740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2019.103280 |
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