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Interdependent Sequence-Selectivity and Diastereoselectivity in the Alkylation of DNA by Decarbamoylmitomycin C.
Mitomycin C (MC), an antitumor drug, and decarbamoylmitomycin C (DMC), a derivative of MC, alkylate DNA and form deoxyguanosine monoadducts and interstrand crosslinks (ICLs). Interestingly, in mammalian culture cells, MC forms primarily deoxyguanosine adducts with a 1”-R stereochemistry at the guani...
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| Publicado no: | Chemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7152928/ https://ncbi.nlm.nih.gov/pubmed/29958326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201802038 |
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